CRISPR Decoded
Research
Landmark papers, summarised in plain language and linked to the original publication.
11 research in CRISPR Decoded. We summarise and link out. We do not reproduce copyrighted journal articles.
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Intervening sequences of regularly spaced prokaryotic repeats derive from foreign genetic elements
The insight that CRISPR spacers come from viruses: the origin of the whole field.
CRISPR provides acquired resistance against viruses in prokaryotes
The experiment, performed at a yogurt company, that proved CRISPR is a bacterial immune system.
A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity
The paper that turned CRISPR from a curiosity of bacterial immunity into a programmable tool.
Multiplex genome engineering using CRISPR/Cas systems
One of the two January 2013 papers showing that CRISPR works inside human cells.
RNA-guided human genome engineering via Cas9
The companion January 2013 paper from George Church's laboratory, published the same day.
Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage
The paper that introduced base editing: chemistry instead of cutting.
Search-and-replace genome editing without double-strand breaks or donor DNA
The paper introducing prime editing: writing new sequence directly into the genome.
CRISPR-Cas9 gene editing for sickle cell disease and β-thalassemia
The first published clinical results showing CRISPR editing produced benefit in patients.
CRISPR-Cas9 in vivo gene editing for transthyretin amyloidosis
The first report of CRISPR administered into a human bloodstream to edit a gene inside the body.
Patient-specific in vivo gene editing to treat a rare genetic disease
The first gene-editing medicine designed and manufactured for a single patient.
Prime editing for p47phox-deficient chronic granulomatous disease
The first published evidence that prime editing works in human patients.