Research
Important Discoveries in Gene Editing
The papers that changed what was possible, each summarised and linked to the original.
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Eleven papers, from the first recognition of what CRISPR was for to the first patients treated with prime editing. Each entry explains what changed and links to the original publication.
| # | Entri | Kategori | Status |
|---|---|---|---|
| 1 | A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity The paper that turned CRISPR from a curiosity of bacterial immunity into a programmable… | Foundational | |
| 2 | Multiplex genome engineering using CRISPR/Cas systems One of the two January 2013 papers showing that CRISPR works inside human cells. | Foundational | |
| 3 | RNA-guided human genome engineering via Cas9 The companion January 2013 paper from George Church's laboratory, published the same day. | Foundational | |
| 4 | Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage The paper that introduced base editing — chemistry instead of cutting. | Method | |
| 5 | Search-and-replace genome editing without double-strand breaks or donor DNA The paper introducing prime editing — writing new sequence directly into the genome. | Method | |
| 6 | CRISPR provides acquired resistance against viruses in prokaryotes The experiment, performed at a yogurt company, that proved CRISPR is a bacterial immune… | Foundational | |
| 7 | CRISPR-Cas9 gene editing for sickle cell disease and β-thalassemia The first published clinical results showing CRISPR editing produced benefit in patients. | Clinical | |
| 8 | CRISPR-Cas9 in vivo gene editing for transthyretin amyloidosis The first report of CRISPR administered into a human bloodstream to edit a gene inside… | Clinical | |
| 9 | Patient-specific in vivo gene editing to treat a rare genetic disease The first gene-editing medicine designed and manufactured for a single patient. | Clinical | |
| 10 | Prime editing for p47phox-deficient chronic granulomatous disease The first published evidence that prime editing works in human patients. | Clinical | |
| 11 | Intervening sequences of regularly spaced prokaryotic repeats derive from foreign genetic elements The insight that CRISPR spacers come from viruses — the origin of the whole field. | Foundational |
Apa yang tidak diberitahu daftar ini kepadamuA curated selection, not a systematic review. We summarise and link; we do not reproduce copyrighted articles.