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Gen · Cancer
BRCA1
BRCA1 DNA repair associated · A DNA repair gene whose loss substantially raises the risk of breast and ovarian cancer, important to gene editing mostly because of the repair pathway it serves.
17q21.31cancerDNA repair
Alleen schematisch, de verhoudingen van de armen zijn bij benadering en de banddetails zijn niet op schaal getekend. Cytogenetische locatie zoals gepubliceerd door NCBI Gene.
Wat dit gen doet
BRCA1 helps repair a specific kind of DNA damage: breaks through both strands. Inherit a broken copy and your cells repair such damage less well, and cancer risk rises substantially. It matters to gene editing for a reason people find surprising: the repair pathway BRCA1 works in is the same one CRISPR relies on when it makes a precise correction.
BRCA1, at 17q21.31, encodes a tumour suppressor central to homologous recombination repair of double-strand breaks. Pathogenic variants confer substantially elevated lifetime risk of breast and ovarian cancer. Its relevance to editing is mechanistic: homology-directed repair, the pathway required for template-based correction after a Cas9 cut, is the pathway BRCA1 serves, and it operates only in dividing cells, which is a fundamental constraint on precise editing.
Sources
MedlinePlus Genetics, U.S. National Library of Medicine BRCA1 gene ↗
Written by CRISPR Decoded editorial teamLast updated Oct 27, 2026
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