La guida definitiva all'editing genico.
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Two molecular structures side by side, linked by threads of light

Strumento

Confronta le tecnologie

Scegli due o tre approcci e scopri le differenze su precisione, taglio del DNA, dimensione del carico, somministrazione, maturità clinica e rischi noti.

Scegli due tecnologie qui sopra, oppure leggi uno dei confronti scritti qui sotto.

Confronti scritti

Le distinzioni che le persone sbagliano più spesso, spiegate come si deve.

CRISPR vs Gene TherapyThe distinction people get wrong most often: one adds a gene, the other changes the one already… CRISPR-Cas9 vs Base EditingCutting versus chemistry: one breaks the DNA and lets the cell repair it, the other rewrites a… Base Editing vs Prime EditingA pencil that changes one letter, against a find-and-replace that can write a short phrase. CRISPR-Cas9 vs Cas12Two nucleases that both cut DNA, differing in where they can aim, how they cut, and what they do… CRISPR vs TALENsRNA aiming against protein aiming, and why one of them took over biology in a year. CRISPR vs Zinc Finger NucleasesThe newcomer against the original, which is compact enough to fit where CRISPR struggles. Ex Vivo vs In Vivo Gene EditingEditing cells outside the body and giving them back, against editing them where they already are. CRISPR vs RNA InterferenceA permanent change to the instructions, against a temporary attack on the copies.

Tutte le tecnologie

Apri il database →
the crystal structure of Streptococcus pyogenes Cas9 in complex with sgRNA and its target DNA at 2.5 A ˚ resolution CRISPR-Cas9A protein that can be programmed with a short RNA guide to find one specific sequence in a genome and cut it. Approved A DNA helix with one letter being chemically changed Base EditingChemically converts one DNA letter into another at a chosen position, without cutting both strands of the double helix. Phase III A prime editor writing new letters into a DNA strand Prime EditingWrites a new stretch of DNA sequence directly into a chosen site, using a guide that carries the replacement text with it. Phase I/II A Cas12 enzyme on DNA, scattering fragments CRISPR-Cas12A family of CRISPR nucleases that cut DNA leaving staggered ends, use a different sequence requirement from Cas9, and can be smaller. Phase I/II A Cas13 enzyme cutting a strand of RNA CRISPR-Cas13Targets RNA rather than DNA, so it can silence a gene's message without touching the genome itself. Phase I A tiny Cas14 enzyme bound to a DNA helix Cas14 and miniature Cas systemsUnusually small CRISPR nucleases, roughly a third the size of Cas9, discovered in archaea and bacteriophages. Discovery An enzyme changing a letter on a strand of RNA RNA EditingChanges letters in the RNA message rather than in the DNA, so the effect is real but temporary and the genome is untouched. Phase I/II A DNA helix studded with glowing chemical tags Epigenetic EditingChanges how loudly a gene is expressed by rewriting the chemical marks on and around it, without altering a single letter of DNA sequence. Preclinical A deactivated Cas9 on DNA beaming light to switch a gene on CRISPRa (gene activation)Uses a disabled CRISPR protein to switch a gene up rather than to cut it. Research tool A deactivated Cas9 sitting on a DNA strand, blocking it CRISPRi (gene silencing)Parks a disabled CRISPR protein on a gene to block it from being read, turning it down without changing it. Research tool TALEN protein arms gripping a DNA helix TALENsCustom-built proteins that recognise DNA letter by letter and cut: the technique CRISPR largely displaced, still in clinical use. Phase I/II Zinc finger proteins binding along a DNA helix Zinc Finger NucleasesThe first programmable gene-editing tool to reach patients: small, engineered proteins that grip DNA in three-letter blocks. Phase III A recombinase enzyme swapping DNA segments Recombinases and integrasesEnzymes that cut and rejoin DNA at defined sites, able to insert whole genes rather than edit single letters. Preclinical A transposase moving a DNA segment to a new place TransposasesEnzymes that cut a segment of DNA out of one place and paste it into another: nature's own copy-and-paste. Phase I/II A viral capsid delivering a gene into a cell Gene Therapy (gene addition)Delivers a working copy of a gene into cells without changing the existing genome. It is the older approach that gene editing is often confused with. Approved An RNA-guided complex unwinding a strand of RNA RNA InterferenceUses the cell's own machinery to destroy a specific RNA message, lowering a protein's level without touching DNA. Approved Modular components being assembled on a bench Synthetic BiologyDesigning genetic parts and circuits so that cells perform new functions: the engineering discipline that gene editing serves as a tool. Phase III