一段话概述
Caribou's distinguishing idea is the guide itself: instead of an all-RNA guide, it uses a hybrid of RNA and DNA, which the company says makes the editing machinery more particular about matching its target exactly. It applies this to off-the-shelf CAR-T cell therapies for blood cancers and autoimmune disease.
Caribou Biosciences was founded in 2011 by Jennifer Doudna, Rachel Haurwitz, Martin Jinek and James Berger. Its chRDNA platform uses hybrid CRISPR RNA-DNA guides with Cas12a, reported to reduce off-target editing. Lead programmes are allogeneic CAR-T candidates including CB-010 (anti-CD19) and CB-011 (anti-BCMA).
Sources
- Caribou Biosciences
Caribou Biosciences pipeline ↗
非投资建议
本档案为依据公开披露信息汇编的教育性资料，不构成对任何证券的买入、卖出或持有建议，也不代表对该公司前景的任何判断。生物技术领域具有高度投机性，大多数临床项目最终以失败告终。
完整免责声明 →