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Treatment · Cancer

CB-010

An allogeneic CAR-T candidate built with hybrid RNA-DNA guides rather than conventional guide RNAs, intended to cut off-target editing.

Phase I cell therapyallogeneicCas12a
Clinical research Being tested in people in registered clinical trials. Being in trials is not evidence that a treatment works or is safe.

Penjelasan sederhana

Caribou builds its edited cells using a modified kind of guide — part RNA, part DNA — which the company says makes the editing machinery fussier about where it cuts. CB-010 is an off-the-shelf CAR-T made this way, with an extra edit that removes a brake on the engineered cells so they keep working longer.

Pelajari lebih dalam

CB-010 is an allogeneic anti-CD19 CAR-T candidate from Caribou Biosciences produced using chRDNA (hybrid CRISPR RNA-DNA) guides with Cas12a, incorporating TRAC insertion of the CAR and PDCD1 knockout to improve persistence. In development for B-cell non-Hodgkin lymphoma and autoimmune indications.

Sources

Written by The CRISPR Atlas editorial team Last updated Aug 25, 2026

Connected in the Atlas

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Technologies

CRISPR-Cas12

Diseases

Leukemia and Lymphoma

Clinical Trials

A Study of CB-010 in Subjects With Relapsed or Refractory B Cell Non-Hodgkin Lymphoma

Genes

PDCD1TRAC

Companies

Caribou Biosciences
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