Clinical research
Being tested in people in registered clinical trials. Being in trials is not evidence that a treatment works or is safe.
Simple explanation
Caribou builds its edited cells using a modified kind of guide, part RNA and part DNA, which the company says makes the editing machinery fussier about where it cuts. CB-010 is an off-the-shelf CAR-T made this way, with an extra edit that removes a brake on the engineered cells so they keep working longer.
Go deeper
CB-010 is an allogeneic anti-CD19 CAR-T candidate from Caribou Biosciences produced using chRDNA (hybrid CRISPR RNA-DNA) guides with Cas12a, incorporating TRAC insertion of the CAR and PDCD1 knockout to improve persistence. In development for B-cell non-Hodgkin lymphoma and autoimmune indications.
Sources
- Caribou Biosciences
Caribou Biosciences pipeline ↗