Простое объяснение
Andrew Anzalone came up with the core idea behind prime editing: what if the guide RNA carried the replacement text as well as the address? He worked it out as a postdoctoral researcher and became first author on the paper that introduced the technique, then joined the company founded to develop it.
Углубиться в тему
Andrew Anzalone conceived and led the development of prime editing in David Liu's laboratory at the Broad Institute, first-authoring the 2019 Nature paper. He subsequently joined Prime Medicine as a scientific leader.
Sources
- Nature (Anzalone et al.) · 2019
Search-and-replace genome editing without double-strand breaks or donor DNA ↗