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Research paper · Method
Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage
The paper that introduced base editing — chemistry instead of cutting.
Simple explanation
This paper showed you could change a single DNA letter without cutting the double helix at all, by attaching a chemical enzyme to a disabled CRISPR protein. It removed the most dangerous step in gene editing.
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Komor, Kim, Packer, Zuris and Liu fused a cytidine deaminase to catalytically impaired Cas9, converting C•G to T•A within a small editing window without generating double-strand breaks, and improved efficiency by including a uracil glycosylase inhibitor and a nickase.
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This page is a reference, not medical advice. Research and regulatory status change; check the last-updated date above and confirm anything important against the primary sources listed.