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인터페이스 언어
라이트 모드
Science2013Cong et al.One of the two January 2013 papers showing that CRISPR works inside human cells.
Research paper · Foundational
Multiplex genome engineering using CRISPR/Cas systems
One of the two January 2013 papers showing that CRISPR works inside human cells.
간단한 설명
Working in a test tube is one thing; working inside a living human cell, with its packed chromosomes and defence systems, is another. This paper showed CRISPR editing human and mouse cells, and doing several edits at once.
더 깊이 알아보기
Cong, Ran, Cox, Lin, Barretto, Habib, Hsu, Wu, Jiang, Marraffini and Zhang demonstrated CRISPR-Cas9 genome editing in human and mouse cells, including multiplexed editing at several loci simultaneously and use of a Cas9 nickase to reduce off-target activity.