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What is a chromosome?

A chromosome is one very long DNA molecule packaged with proteins; humans normally have 46, in 23 pairs.

简短解答

Your DNA is not one continuous thread but 46 separate ones, each wound up with proteins into a structure called a chromosome. They come in 23 pairs — one of each pair from each parent. Twenty-two pairs look the same in everyone; the last pair, the sex chromosomes, differ.

Chromosomes are DNA molecules complexed with histone and non-histone proteins to form chromatin. Humans typically have 46 chromosomes in 23 pairs: 22 autosome pairs and one sex chromosome pair. Each has a centromere dividing it into a short (p) and long (q) arm, and telomeres capping its ends. Cytogenetic location — the notation used on this site's gene pages, such as 11p15.4 — refers to a chromosome, an arm and a banding position.

How to read a gene address

Gene locations are written in a fixed format. HBB is at 11p15.4: chromosome 11, short arm (p), band 15, sub-band 4. The gene pages on this site draw that position on a schematic chromosome so you can see roughly where in the genome a gene sits.

Where the analogy breaks downChromosome pictures are drawn as neat banded rods with a pinched waist, but that is only what they look like during cell division. For most of a cell's life chromosomes are decondensed and tangled through the nucleus, nothing like the diagram.

Sources

Connected in the Atlas

Every entry on this site is linked to the others it relates to. These connections are part of the record, not a search result.