Clinical research
Being tested in people in registered clinical trials. Being in trials is not evidence that a treatment works or is safe.
What this trial is testing
A trial of an off-the-shelf CAR-T therapy that carries several CRISPR edits at once — some to stop the donor cells attacking the patient, some intended to help them survive and work longer inside the body.
A Phase 1/2 study of CTX112, an allogeneic anti-CD19 CAR-T candidate incorporating multiple CRISPR edits for allogeneic compatibility and potency, in relapsed or refractory B-cell malignancies. CTX112 holds FDA Regenerative Medicine Advanced Therapy designation.
Sources
- CRISPR Therapeutics
CRISPR Therapeutics pipeline ↗
What a trial result does and does not mean
Early-phase results come from small numbers of participants and short follow-up. They can change with more people and more time, and a trial that is recruiting, active or even completed has not established that a treatment works. Enrolment criteria are strict; eligibility is decided by the trial site, never by a website.