Clinical research
Being tested in people in registered clinical trials. Being in trials is not evidence that a treatment works or is safe.
本试验正在测试什么
A trial of an off-the-shelf CAR-T therapy for lymphoma, made from healthy donor cells edited so they can be given to unrelated patients. It uses a modified guide — part RNA, part DNA — that the company says makes the editing more precise.
A Phase 1 study of CB-010, an allogeneic anti-CD19 CAR-T cell therapy manufactured using chRDNA hybrid guides with Cas12a, incorporating CAR insertion at TRAC and PDCD1 knockout, in relapsed or refractory B-cell non-Hodgkin lymphoma.
Sources
- Caribou Biosciences
Caribou Biosciences pipeline ↗
试验结果意味着什么，又不意味着什么
早期试验结果来自少量参与者和较短的随访周期，随着人数增加和时间延长，结论可能发生变化。正在招募、进行中甚至已完成的试验，并不代表某种疗法已被证实有效。入组标准十分严格，是否符合条件由试验机构决定，而非由网站判断。