Clinical research
Being tested in people in registered clinical trials. Being in trials is not evidence that a treatment works or is safe.
What this trial is testing
A trial of an off-the-shelf CAR-T therapy for lymphoma, made from healthy donor cells edited so they can be given to unrelated patients. It uses a modified guide — part RNA, part DNA — that the company says makes the editing more precise.
A Phase 1 study of CB-010, an allogeneic anti-CD19 CAR-T cell therapy manufactured using chRDNA hybrid guides with Cas12a, incorporating CAR insertion at TRAC and PDCD1 knockout, in relapsed or refractory B-cell non-Hodgkin lymphoma.
Sources
- Caribou Biosciences
Caribou Biosciences pipeline ↗
What a trial result does and does not mean
Early-phase results come from small numbers of participants and short follow-up. They can change with more people and more time, and a trial that is recruiting, active or even completed has not established that a treatment works. Enrolment criteria are strict; eligibility is decided by the trial site, never by a website.