{"meta":{"source":"CRISPR Decoded","note":"Headlines and links only. Articles remain the property of the publishers named."},"data":[{"slug":"backed-by-amish-and-mennonites-a-new-kind-of-gene-therapy-company-take-da4d23","title":"Backed by Amish and Mennonites, a new kind of gene therapy company takes shape","url":"https://endpoints.news/backed-by-amish-and-mennonites-a-new-kind-of-gene-therapy-company-takes-shape/","publisher":"Endpoints News","summary":"LANCASTER, PA — This spring, Lorraine and Mark Martin, a Mennonite family with a tax business, adopted a stubby-legged cow named Royal Lite. Lorraine, Mark and Royal Lite all have one thing in common: They ...","category":"Treatments","published":"2026-10-27 20:52:03+00:00"},{"slug":"rice-plants-can-fight-off-devastating-disease-after-gene-editing-with--c3af43","title":"Rice plants can fight off devastating disease after gene editing with AI-designed tool","url":"https://phys.org/news/2026-10-rice-devastating-disease-gene-ai.html","publisher":"Phys.org — Molecular Biology","summary":"University of Missouri researchers have created rice plants that resist bacterial blight, a devastating disease that threatens one of the world's most important food crops. The advance could help farmers in parts of Asia and Africa, where the disease can destroy harvests and threaten livelihoods.","category":"Agriculture","published":"2026-10-27 20:20:15+00:00"},{"slug":"stat-after-two-deaths-in-autoimmune-cell-therapy-trial-artiva-is-shutt-a5ccac","title":"STAT+: After two deaths in autoimmune cell therapy trial, Artiva is shutting down","url":"https://www.statnews.com/2026/10/27/autoimmune-cell-therapy-trial-artiva-therapeutics-shutting-down/?utm_campaign=rss","publisher":"STAT","summary":"Recent deaths are setbacks in drug companies’ interest in applying cancer therapy strategies to autoimmune diseases.","category":"Treatments","published":"2026-10-27 18:05:13+00:00"},{"slug":"bonjour-genomics-a-video-from-ashg-6aa339","title":"Bonjour Genomics: A Video from ASHG","url":"https://www.genengnews.com/topics/omics/bonjour-genomics-a-video-from-ashg/","publisher":"GEN — Genetic Engineering News","summary":"GEN editors Uduak Thomas and Julianna LeMieux, PhD, recap ASHG, highlighting key sessions, Ultima Genomics’ user group meeting, Illumina news, and insights from PacBio’s new CEO Mark Van Oene. The post Bonjour Genomics: A Video from ASHG appeared first on GEN - Genetic Engineering and Biotechnology…","category":"Companies","published":"2026-10-27 17:18:55+00:00"},{"slug":"artiva-to-wind-down-after-two-patient-deaths-in-autoimmune-cell-therap-6e47b3","title":"Artiva to wind down after two patient deaths in autoimmune cell therapy trials","url":"https://endpoints.news/artiva-to-wind-down-after-two-patient-deaths-in-autoimmune-cell-therapy-trials/","publisher":"Endpoints News","summary":"Cell therapy biotech Artiva Biotherapeutics abruptly announced Tuesday morning that it is effectively shutting down and laying off almost all of its staff after two patients died in its clinical trials. Researchers had been testing ...","category":"Clinical Trials","published":"2026-10-27 14:45:41+00:00"},{"slug":"outpace-ends-an-ovarian-cancer-trial-incyte-data-impresses-at-esmo-766444","title":"Outpace ends an ovarian cancer trial; Incyte data impresses at ESMO","url":"https://endpoints.news/outpace-ends-an-ovarian-cancer-trial-incyte-data-impresses-at-esmo/","publisher":"Endpoints News","summary":"Plus news about Genmab, Rumi, Prana and Fractyl. Outpace Bio ends cell therapy trial: The Seattle startup canned a Phase 1 ovarian cancer trial of its mesothelin autologous CAR-T, called OPB-101 ...","category":"Clinical Trials","published":"2026-10-27 14:38:38+00:00"},{"slug":"stat-nonprofit-resurrects-shelved-gene-therapy-after-startup-shuts-dow-22e507","title":"STAT+: Nonprofit resurrects shelved gene therapy after startup shuts down","url":"https://www.statnews.com/2026/10/27/biotech-news-nonprofit-resurrects-shelved-gene-therapy/?utm_campaign=rss","publisher":"STAT","summary":"Last year, U.K. gene therapy startup Bloomsbury Genetic Therapies announced it was shutting down after dosing just one patient. Now, a nonprofit is resurrecting its lead program:","category":"Treatments","published":"2026-10-27 14:28:10+00:00"},{"slug":"spatial-proteomics-for-precision-oncology-e362a5","title":"Spatial Proteomics for Precision Oncology","url":"https://www.genengnews.com/multimedia/webinars/spatial-proteomics-for-precision-oncology/","publisher":"GEN — Genetic Engineering News","summary":"In this GEN webinar, Bernd Bodenmiller, PhD (University of Zürich), illustrates this integrated approach through two recent examples. The post Spatial Proteomics for Precision Oncology appeared first on GEN - Genetic Engineering and Biotechnology News .","category":"Companies","published":"2026-10-26 19:57:45+00:00"},{"slug":"stat-pharmalittle-we-re-reading-about-a-roche-lung-cancer-drug-a-brist-dc0313","title":"STAT+: Pharmalittle: We’re reading about a Roche lung cancer drug, a Bristol CAR-T trial death, and more","url":"https://www.statnews.com/pharmalot/2026/10/26/roche-lung-cancer-drug-patient-death-in-bristol-trial/?utm_campaign=rss","publisher":"STAT","summary":"Bristol Myers Squibb reported that one patient died after receiving its investigational CAR-T therapy in an early autoimmune trial","category":"Treatments","published":"2026-10-26 13:37:51+00:00"},{"slug":"author-correction-in-vivo-mitochondrial-base-editing-restores-genotype-2bd50b","title":"Author Correction: In vivo mitochondrial base editing restores genotype and visual function in a mouse model of LHON","url":"https://www.nature.com/articles/s41467-026-79197-y","publisher":"Nature Genetics","summary":"","category":"Research","published":"2026-10-26 00:00:00+00:00"},{"slug":"stat-patient-dies-in-bristol-myers-squibb-autoimmune-car-t-trial-a2af70","title":"STAT+: Patient dies in Bristol Myers Squibb autoimmune CAR-T trial","url":"https://www.statnews.com/2026/10/23/bristol-myers-squibb-car-t-therapy-autoimmune-trial-death/?utm_campaign=rss","publisher":"STAT","summary":"Where should the safety bar be for studies investigating CAR-T therapies for autoimmune conditions?","category":"Companies","published":"2026-10-23 18:55:12+00:00"},{"slug":"q-a-bristol-myers-lynelle-hoch-on-autoimmune-car-t-safety-challenges-c14e8e","title":"Q&A: Bristol Myers' Lynelle Hoch on autoimmune CAR-T safety challenges","url":"https://endpoints.news/qa-bristol-myers-lynelle-hoch-on-autoimmune-car-t-safety-challenges/","publisher":"Endpoints News","summary":"Bristol Myers Squibb is facing one problem after another with its autoimmune CAR-T therapy program. The company says it has figured out the cause of the safety signal in a lupus trial ...","category":"Treatments","published":"2026-10-23 18:36:40+00:00"},{"slug":"bristol-myers-reveals-death-in-ms-car-t-trial-has-answer-for-safety-si-0ae0a2","title":"Bristol Myers reveals death in MS CAR-T trial, has answer for safety signal in lupus trial","url":"https://endpoints.news/bristol-myers-reveals-autoimmune-car-t-trial-death-explains-summertime-pause/","publisher":"Endpoints News","summary":"A patient has died in a Bristol Myers Squibb study of autoimmune CAR-T, the same technology that was called into question this summer when both Bristol Myers and Novartis paused similar programs. The patient, who ...","category":"Companies","published":"2026-10-23 14:33:54+00:00"},{"slug":"a-quick-squeeze-helps-crispr-turn-skin-cells-into-neurons-more-efficie-4ca66f","title":"A quick squeeze helps CRISPR turn skin cells into neurons more efficiently","url":"https://phys.org/news/2026-10-quick-crispr-skin-cells-neurons.html","publisher":"Phys.org — Molecular Biology","summary":"Human cells hold about two meters (6.6 feet) of DNA, folded and compacted to fit inside a nucleus. That packing is essential for life, but it creates a problem for scientists. Some of the genes that control a cell's identity are buried so deep in tightly packed DNA that gene-targeting tools such as…","category":"Research","published":"2026-10-23 13:20:09+00:00"},{"slug":"new-gene-editing-approach-shows-promise-in-treating-huntington-s-disea-299147","title":"New gene-editing approach shows promise in treating Huntington's disease in mice","url":"https://medicalxpress.com/news/2026-10-gene-approach-huntington-disease-mice.html","publisher":"Medical Xpress — Genetics","summary":"Huntington's disease is caused by repetitive \"stutters\" in DNA—specifically repeated CAG sequences—that expand abnormally over time, leading to toxic protein accumulation that contributes to the progression of the disease. There is currently no cure for this rare and fatal genetic disease.","category":"Research","published":"2026-10-22 19:40:06+00:00"},{"slug":"using-ai-agents-and-bio-foundation-models-to-automate-vector-design-fo-1e5092","title":"Using AI Agents and Bio-Foundation Models to Automate Vector Design for Cell Line Development","url":"https://www.genengnews.com/multimedia/webinars/using-ai-agents-and-bio-foundation-models-to-automate-vector-design-for-cell-line-development/","publisher":"GEN — Genetic Engineering News","summary":"In this GEN webinar, Asimov’s VP of Business Development and Commercial Strategy Jamie Freeman, PhD, will show how Asimov combines bio-foundation models, AI agents, and synthetic biology to tailor expression vector design for each molecule. The post Using AI Agents and Bio-Foundation Models to…","category":"Research","published":"2026-10-21 18:14:18+00:00"},{"slug":"patients-should-be-considered-when-choosing-a-vector-production-method-b505d1","title":"Patients Should Be Considered When Choosing a Vector Production Method","url":"https://www.genengnews.com/topics/bioprocessing/patients-should-be-considered-when-choosing-a-vector-production-method/","publisher":"GEN — Genetic Engineering News","summary":"Vector production costs have a disproportionate influence on gene therapy prices, according to researchers who say that, given this, choosing the vector manufacturing method that best suits the intended use of the product is vital. The post Patients Should Be Considered When Choosing a Vector…","category":"Agriculture","published":"2026-10-21 16:00:00+00:00"},{"slug":"pooled-crispr-screens-identify-genes-and-non-coding-genomic-regions-th-759964","title":"Pooled CRISPR screens identify genes and non-coding genomic regions that regulate red blood cell density","url":"https://www.nature.com/articles/s42003-026-11204-w","publisher":"Nature Genetics","summary":"","category":"Research","published":"2026-10-21 00:00:00+00:00"},{"slug":"improving-prenatal-thalassemia-carrier-detection-with-a-combined-mcv-a-66296f","title":"Improving prenatal thalassemia carrier detection with a combined MCV and MCH strategy: a 24-year retrospective cohort study","url":"https://www.nature.com/articles/s41598-026-77219-9","publisher":"Nature Genetics","summary":"","category":"Research","published":"2026-10-21 00:00:00+00:00"},{"slug":"q-a-gene-editing-is-coming-for-common-diseases-cardiologists-discuss-i-930d03","title":"Q&A: Gene editing is coming for common diseases. Cardiologists discuss if we are ready","url":"https://medicalxpress.com/news/2026-10-qa-gene-common-diseases-cardiologists.html","publisher":"Medical Xpress — Genetics","summary":"Gene therapy is no longer the future of medicine—it's reality. Treatments that replace, silence or edit genes are already changing clinical care.","category":"Treatments","published":"2026-10-20 20:20:15+00:00"},{"slug":"added-receptor-helps-car-t-cells-stay-in-bone-marrow-in-cancer-mouse-m-2eca73","title":"Added receptor helps CAR T cells stay in bone marrow in cancer mouse models","url":"https://phys.org/news/2026-10-added-receptor-car-cells-stay.html","publisher":"Phys.org — Molecular Biology","summary":"By turning a patient's own immune cells into stronger cancer-fighting cells, CAR T-cell therapy has transformed how some blood cancers are treated. But it's been harder to extend this approach to solid tumors, including cancer that has spread to the bone.","category":"Treatments","published":"2026-10-20 13:00:01+00:00"},{"slug":"canada-s-arctic-research-could-help-discover-next-gen-therapeutics-3f84a0","title":"Canada’s Arctic Research Could Help Discover Next-Gen Therapeutics","url":"https://www.genengnews.com/topics/drug-discovery/canadas-arctic-research-could-help-discover-next-gen-therapeutics/","publisher":"GEN — Genetic Engineering News","summary":"Unlocking the Arctic’s subterranean DNA must ensure a delicate balance between scientific rigor and ethical stewardship. Synthetic biology and chemistry could help discovery of new life-saving therapeutics. The post Canada’s Arctic Research Could Help Discover Next-Gen Therapeutics appeared first…","category":"Ethics","published":"2026-10-20 11:12:39+00:00"},{"slug":"new-crispr-approach-targets-gene-fusions-found-in-1-in-5-cancers-9df9a1","title":"New CRISPR approach targets gene fusions found in 1 in 5 cancers","url":"https://medicalxpress.com/news/2026-10-crispr-approach-gene-fusions-cancers.html","publisher":"Medical Xpress — Genetics","summary":"Peter Mac scientists have developed a way to precisely target the \"unique molecular fingerprint\" created when two genes become abnormally fused together, a discovery that could lead to a new way to treat a wide array of cancers.","category":"Research","published":"2026-10-19 17:20:22+00:00"},{"slug":"merck-kgaa-to-buy-silence-therapeutics-and-its-sirna-pipeline-for-1-3b-8c6f35","title":"Merck KGaA to buy Silence Therapeutics and its siRNA pipeline for $1.3B","url":"https://endpoints.news/merck-kgaa-will-buy-silence-therapeutics-and-its-sirna-pipeline-for-1-3b/","publisher":"Endpoints News","summary":"Germany's Merck KGaA agreed to buy UK drug developer Silence Therapeutics for $1.3 billion, building out its work in rare and specialty diseases using genetic medicines. Silence is developing the siRNA drug divesiran, which is ...","category":"M&A","published":"2026-10-19 13:57:45+00:00"},{"slug":"statistical-correlation-between-strength-and-mini-dystrophin-expressio-948442","title":"Statistical correlation between strength and mini-dystrophin expression in skeletal muscle after an rAAV9-mini-dystrophin gene therapy candidate in DMDmdx rats","url":"https://www.nature.com/articles/s41434-026-00648-8","publisher":"Nature Genetics","summary":"","category":"Treatments","published":"2026-10-17 00:00:00+00:00"},{"slug":"adc-developmentfrom-concept-to-clinic-5ffa2d","title":"ADC Development from Concept to Clinic","url":"https://www.genengnews.com/resources/ebooks/adc-developmentfrom-concept-to-clinic/","publisher":"GEN — Genetic Engineering News","summary":"This eBook brings insight on integrated end-to-end solutions for precision engineered therapeutics. The post ADC Development from Concept to Clinic appeared first on GEN - Genetic Engineering and Biotechnology News .","category":"Companies","published":"2026-10-16 20:36:42+00:00"},{"slug":"designing-the-ecosystem-for-cgt-success-68f133","title":"Designing the Ecosystem for CGT Success","url":"https://www.genengnews.com/resources/ebooks/designing-the-ecosystem-for-cgt-success/","publisher":"GEN — Genetic Engineering News","summary":"This proceedings eBook, developed in partnership with GEN and Cincinnati Children’s Hospital Applied Gene and Cell Therapy Center, captures perspectives and lessons from The Cell Summit ’26 and extends the conversation beyond the meeting itself. The post Designing the Ecosystem for CGT Success…","category":"Treatments","published":"2026-10-16 17:21:49+00:00"},{"slug":"estuary-debuts-with-103m-to-develop-kidney-disease-gene-therapies-13f5e6","title":"Estuary debuts with $103M to develop kidney disease gene therapies","url":"https://endpoints.news/estuary-debuts-with-103m-to-develop-kidney-disease-gene-therapies/","publisher":"Endpoints News","summary":"Estuary Biotherapeutics raised the curtain on Friday with $103 million to support the advancement of two preclinical gene therapy candidates for the most common type of inherited kidney disease. The company’s cash comes from a ...","category":"Funding","published":"2026-10-16 10:30:34+00:00"},{"slug":"proteomics-reveals-ovarian-remodeling-decades-after-menopause-0fa7aa","title":"Proteomics Reveals Ovarian Remodeling Decades After Menopause","url":"https://www.genengnews.com/topics/omics/proteomics-reveals-ovarian-remodeling-decades-after-menopause/","publisher":"GEN — Genetic Engineering News","summary":"5,812 protein groups were quantified in postmenopausal ovaries, uncovering molecular shifts associated with inflammation, immunity, and extracellular matrix remodeling. The post Proteomics Reveals Ovarian Remodeling Decades After Menopause appeared first on GEN - Genetic Engineering and…","category":"Research","published":"2026-10-15 22:16:35+00:00"},{"slug":"molecular-snapshots-reveal-how-viral-enzymes-switch-between-inserting--d7048d","title":"Molecular snapshots reveal how viral enzymes switch between inserting and removing DNA","url":"https://phys.org/news/2026-10-molecular-snapshots-reveal-viral-enzymes.html","publisher":"Phys.org — Molecular Biology","summary":"Bacteriophages, or viruses that infect bacteria, have a fiendishly simple purpose in life: attach to a bacterial cell, inject their DNA and then use the host's genetic machinery to reproduce. In doing so, they may have evolved some of the most efficient gene-editing tools ever seen in nature.","category":"Research","published":"2026-10-15 21:00:01+00:00"},{"slug":"paul-stoffels-to-bring-galapagos-cell-therapies-back-to-life-9b03ef","title":"Paul Stoffels to bring Galapagos’ cell therapies back to life","url":"https://endpoints.news/paul-stoffels-to-bring-galapagos-cell-therapies-back-to-life/","publisher":"Endpoints News","summary":"Paul Stoffels isn’t giving up on the cell therapy plans he had at Galapagos, the Belgian drug developer that he tried turning around as CEO before abruptly departing last year. A new biotech called Armed ...","category":"Treatments","published":"2026-10-15 10:33:24+00:00"},{"slug":"engineered-enzyme-could-improve-detection-of-hiv-and-other-viruses-cfb725","title":"Engineered enzyme could improve detection of HIV and other viruses","url":"https://phys.org/news/2026-10-enzyme-hiv-viruses.html","publisher":"Phys.org — Molecular Biology","summary":"Scientists have long used a powerful gene-editing tool called CRISPR to make precise changes to DNA. But a different version of the technology, known as Cas13a, targets RNA, the genetic material found in viruses such as HIV. Now, researchers at Rice University have developed an improved version of…","category":"Agriculture","published":"2026-10-14 21:00:11+00:00"},{"slug":"cell-therapy-manufacturing-takes-shape-across-asia-pacific-38ca6a","title":"Cell Therapy Manufacturing Takes Shape Across Asia-Pacific","url":"https://www.genengnews.com/topics/bioprocessing/cell-therapy-manufacturing-takes-shape-across-asia-pacific/","publisher":"GEN — Genetic Engineering News","summary":"Cell and gene therapy is accelerating across Asia-Pacific, but manufacturing remains fragmented. Strategic automation, adaptable bioprocessing platforms, stronger supply chains, and workforce development could help therapies scale across diverse markets. The post Cell Therapy Manufacturing Takes…","category":"Treatments","published":"2026-10-14 16:00:29+00:00"},{"slug":"contracting-expansion-a-path-to-better-car-t-cell-therapy-production-852912","title":"Contracting Expansion: A Path to Better CAR T-Cell Therapy Production","url":"https://www.genengnews.com/topics/bioprocessing/contracting-expansion-a-path-to-better-car-t-cell-therapy-production/","publisher":"GEN — Genetic Engineering News","summary":"Shorter cell expansion steps could significantly accelerate CAR T-cell therapy production processes, according to researchers, who cite microfluidic culture systems, real-time PAT tools, and AI-enabled predictive models as key enablers of this new rapid manufacturing paradigm. The post Contracting…","category":"Treatments","published":"2026-10-14 16:00:01+00:00"},{"slug":"arrowhead-s-brain-targeting-rna-drug-lowers-alzheimer-s-protein-in-ear-13f75f","title":"Arrowhead’s brain-targeting RNA drug lowers Alzheimer’s protein in early study","url":"https://endpoints.news/arrowheads-brain-targeting-rna-drug-lowers-alzheimers-protein-in-early-study/","publisher":"Endpoints News","summary":"Arrowhead Pharmaceuticals has shown that a genetic medicine administered as a subcutaneous injection can seemingly travel into the brain and lower levels of tau, a protein implicated in Alzheimer’s disease. The company found that the ...","category":"Treatments","published":"2026-10-14 11:30:27+00:00"},{"slug":"prime-editing-repairs-immune-disorder-defect-in-patient-s-own-blood-st-4fb9df","title":"Prime editing repairs immune disorder defect in patient's own blood stem cells","url":"https://medicalxpress.com/news/2026-10-prime-immune-disorder-defect-patient.html","publisher":"Medical Xpress — Genetics","summary":"Some people are born with a defect in their genetic material that prevents their immune system from functioning properly. In people with a condition known as GATA2 deficiency, the body does not produce enough immune cells, leaving them at increased risk of infections and disease. Now, researchers…","category":"Research","published":"2026-10-13 19:20:07+00:00"},{"slug":"a-small-rna-switch-with-huge-potential-opens-up-new-possibilities-for--13581c","title":"A small RNA switch with huge potential opens up new possibilities for synthetic biology","url":"https://phys.org/news/2026-10-small-rna-huge-potential-possibilities.html","publisher":"Phys.org — Molecular Biology","summary":"An international research team led by TU Darmstadt Professor Beatrix Süß, working in close collaboration with partners in Germany and Denmark, has elucidated how an RNA switch newly developed at TU Darmstadt recognizes the antibiotic doxycycline and thereby selectively activates or deactivates gene…","category":"Scientists","published":"2026-10-13 17:02:08+00:00"},{"slug":"beam-suggests-it-can-correct-mutation-pfizer-to-collaborate-with-enodi-de670b","title":"Beam suggests it can correct mutation; Pfizer to collaborate with Enodia","url":"https://endpoints.news/beam-proves-it-can-correct-mutation-pfizer-to-collaborate-with-enodia/","publisher":"Endpoints News","summary":"Beam's first data on a rare disease gene editing therapy: Beam Therapeutics shared initial data from a Phase 1/2 trial of a base editing therapy for glycogen storage disease type Ia ...","category":"Clinical Trials","published":"2026-10-13 15:37:36+00:00"},{"slug":"bacterial-antiviral-defense-suggests-ancient-link-to-human-chromosome--f8e421","title":"Bacterial antiviral defense suggests ancient link to human chromosome protection","url":"https://phys.org/news/2026-10-bacterial-antiviral-defense-ancient-link.html","publisher":"Phys.org — Molecular Biology","summary":"A new antiviral defense system discovered by Columbia scientists could be adapted in the future into a gene editor that slows down aging in our cells and improves cancer therapies. At the same time, the discovery also sheds light on an ancient event in evolution that may have helped set the stage…","category":"Research","published":"2026-10-12 22:20:02+00:00"},{"slug":"stockwatch-caribou-plunges-as-it-pursues-strategic-alternatives-aa4442","title":"StockWatch: Caribou Plunges as It Pursues Strategic Alternatives","url":"https://www.genengnews.com/topics/genome-editing/stockwatch-caribou-plunges-as-it-pursues-strategic-alternatives/","publisher":"GEN — Genetic Engineering News","summary":"Caribou has halted trials of vispacabtagene regedleucel (vispa-cel, formerly CB-010) a treatment for relapsed or refractory B cell non-Hodgkin lymphoma; and of CB-011, an allogeneic anti-BCMA CAR-T cell therapy for the treatment of patients with r/r multiple myeloma. The post StockWatch: Caribou…","category":"Treatments","published":"2026-10-12 19:48:28+00:00"}]}